Heme Review
Heme Review
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The More Data You Have, The Further You Are From The Truth
Dr Pavlos Msaouel: faculty.mdanderson.org/profiles/pavlos_msaouel.html
Produced by @chubbyemu
Audio only version: spotifyanchor-web.app.link/e/C3WPkgNWZzb
0:00 Pretext and context MD Anderson Cancer Center
1:42 The Early Experiences That Shaped Dr Msaouel
3:39 The System of Cancer Research In the United States
5:25 FDA Drug Approvals and Special Designations For Oncology
11:09 A trade-off in our current system
12:35 Whoops 😞 I misspoke
14:35 Randomized trials are not supposed to be representative of a population
18:10 Inference for the treatment of Katie Coleman (metastatic oncocytoma)
25:12 It is much more valuable to refute hypotheses than to confirm them
28:05 All Models Are Wrong, But Some Are Useful
30:05 Recasting the Bias-Variance Trade-off as the Patient Relevance-Robustness Trade-off
33:38 High Relevance, Low Robustness: Subjective Bayes
34:46 High Robustness, Low Relevance: Pure Randomization
41:47 Signal To Noise Ratio
45:49 The Big Data Paradox
53:41 How the Big Data Paradox fits in with Katie Coleman's case
54:33 How the Big Data Paradox fits in with other branches of medicine
57:54 How do we rectify subjectivity in The Truth?
01:00:43 How do we address the problems introduced by the Big Data Paradox?
01:04:21 Duality in nature and a Twitter argument re: the Evidence-Based Deep Medicine Iceberg
01:07:03 Why the ideas coming from MD Anderson are coming from MD Anderson
01:09:39 Where you can find Dr Msaouel
Dr Msaouel: PavlosMsaouel
Heme Review: HemeReview
Production Assistant: Nick Brown
Secret channel: @BigEmus
Cancer Patient Speaks With Her Oncologist ► ua-cam.com/video/Nddft_nc3Yc/v-deo.html
A Woman Had A Headache Lasting 3 Days (Katie's case) ► ua-cam.com/video/i9fLEvgZzRE/v-deo.html
References:
Stephen Senn. Statistical Issues in Drug Development.
Why representativeness should be avoided. academic.oup.com/ije/article/42/4/1012/656034
Commentary: Representativeness is usually not necessary and often should be avoided. academic.oup.com/ije/article/42/4/1018/658638
Impervious to Randomness: Confounding and Selection Biases in Randomized Clinical Trials. www.tandfonline.com/doi/full/10.1080/07357907.2021.1974030
A Causal Framework for Making Individualized Treatment Decisions in Oncology. www.mdpi.com/2072-6694/14/16/3923
Causal Diagram Techniques for Urologic Oncology Research. www.sciencedirect.com/science/article/pii/S1558767320301932
Causal inference and the data-fusion problem.
www.pnas.org/doi/10.1073/pnas.1510507113
Causal Inference: What If. Miguel A Hernán and James M. Robins. www.hsph.harvard.edu/miguel-hernan/wp-content/uploads/sites/1268/2023/04/hernanrobins_WhatIf_31mar23.pdf
There is Individualized Treatment. Why Not Individualized Inference? arxiv.org/abs/1510.08539
Unrepresentative big surveys significantly overestimated US vaccine uptake. www.nature.com/articles/s41586-021-04198-4
Unrepresentative Big Surveys Significantly Overestimate US Uptake arxiv.org/pdf/2106.05818.pdf
Statistical Modeling: The Three Cultures. hdsr.mitpress.mit.edu/pub/uo4hjcx6/release/1
How “centaur AI” will radically reshape the future of healthcare. bigthink.com/health/how-centaur-ai-will-radically-reshape-the-future-of-healthcare/
Переглядів: 32 432

Відео

I Abruptly Stopped Drinking Caffeine And This Happened
Переглядів 2,3 млнРік тому
​@chubbyemu Caffeine Dry Scoop: ua-cam.com/video/sylqJ0NEVJw/v-deo.html Happened while filming this video: ua-cam.com/video/LKNfFm0QDXQ/v-deo.html Music by @Lifeformed: lifeformed.bandcamp.com Timestamps: 0:00 Pretext 0:29 I Used To Self-Mix Supplements 2:25 Mixing The Wrong Supplements Causes Accidents 2:54 Caffeine Mechanism of Action 4:12 Caffeine and Sleep 5:09 Why Caffeine Isn't As "Strong...
The Boy Who Put On A Sock That Had A Spider In It
Переглядів 108 тис.Рік тому
@chubbyemu video: ua-cam.com/video/xtVvtsPgfew/v-deo.html Heme Review Podcast: anchor.fm/chubbyemu Behind the scenes channel: @BigEmus Music by @Lifeformed ► lifeformed.bandcamp.com All Heme Review videos (playlist) ► ua-cam.com/play/PLAHeV2H_YiGUYhHOF4wRMCuqBIJvrnWqS.html Daddy Longlegs by Vengolis Loxosceles gaucho by Halies Some images by Getty Images References: CMS Malaque, RS Vetter, M En...
The Boy Who Rubbed 1 Tube Of Pain Relief Cream Between His Legs
Переглядів 111 тис.Рік тому
​@chubbyemu video of this case: ua-cam.com/video/Le-IKCLGT9A/v-deo.html A Toddler Drank His Mom's Essential Oils: ua-cam.com/video/TZr0nt2hxbs/v-deo.html Audio-podcast version of this video: anchor.fm/chubbyemu Interview With a DNP Accident Survivor: ua-cam.com/video/o15HCjtSkug/v-deo.html Tweet me: HemeReview IG me: HemeReview Patient portrayed by Abram Cutshall Mom a...
The Student Who Ate 5-Day Old Pasta And His Liver Shut Down
Переглядів 144 тис.2 роки тому
@chubbyemu video: ua-cam.com/video/5ujTYLV2Qo4/v-deo.html Audio only version: anchor.fm/chubbyemu/episodes/The-Student-Who-Ate-5-Day-Old-Pasta-And-His-Liver-Shut-Down-e1hb47q Tweet me: hemereview IG me: hemereview Main channel: @chubbyemu Behind the scenes channel: @BigEmus A Student Ate 5 Day Old Pasta For Lunch. This Is How His Liver Shut Down. References: Fulminant ...
The Woman Who Ate 23 Bananas After Fasting 7 Days And Had Refeeding Syndrome
Переглядів 155 тис.2 роки тому
@chubbyemu A Woman Ate 23 Bananas: ua-cam.com/video/nQC_GDTNkQQ/v-deo.html A Mom Tried Keto Diet: ua-cam.com/video/W74jOR9V6UA/v-deo.html The Weird Time When Energy Drinks Fixed My Insomnia: ua-cam.com/video/d_qKA6KTvs8/v-deo.html Audio Podcast: anchor.fm/chubbyemu Tweet me: hemereview IG me: hemereview References: Mechanism of hypokalemia in magnesium deficiency. Huan...
The Weird Time When Energy Drinks Fixed My Insomnia
Переглядів 614 тис.2 роки тому
Mug is here 😳 ► crowdmade.com/collections/chubbyemu @chubbyemu energy drink video ► ua-cam.com/video/tAtaIZD0Ebs/v-deo.html A Student Ate Only Chips And Fries For 10 Years ► ua-cam.com/video/VINtwoyaF_8/v-deo.html A Mom Ate 5 Day Old Sushi 🍣 ► ua-cam.com/video/R0d6Dpx2li4/v-deo.html Vitamin B12 deficiency can cause neurologic problems. It's stored in the liver and isn't made in humans. It needs...
Interview With A Renal Medullary Carcinoma Survivor
Переглядів 67 тис.2 роки тому
@chubbyemu video: ua-cam.com/video/3E75UvmY9GA/v-deo.html A Brief Discussion On Renal Medullary Carcinoma: ua-cam.com/video/j7WGP6sJBLk/v-deo.html Audio version of this video: anchor.fm/chubbyemu/episodes/Interview-With-A-Rare-Renal-Medullary-Carcinoma-Survivor-e167o99 Sickle Cell means Sickle Hemoglobinopathy, including Sickle Cell Disease, Sickle Cell Trait, Beta Thalassemia, Sickle Cell Hemo...
A Drepanocyte Caused Vasoocclusion. This Is What Happened To The Renal Medulla.
Переглядів 89 тис.2 роки тому
​@chubbyemu video: ua-cam.com/video/3E75UvmY9GA/v-deo.html Interview with Herman Connor: ua-cam.com/video/w5zLOZE-Goc/v-deo.html Audio version of this podcast available at anchor.fm/chubbyemu/episodes/A-Sickle-Cell-Caused-Vasoocclusion This-Is-What-Happened-To-The-Kidney-Medulla-e1646ln Tweet Dr Msaouel: pavlosmsaouel IG me: hemereview Tweet me: hemereview ...
A Discussion On Breast Malignancy And Military Burn Pit Exposure
Переглядів 56 тис.2 роки тому
@chubbyemu Video: ua-cam.com/video/LKNfFm0QDXQ/v-deo.html Dr Bora Lim is a breast specialist, Associate Professor of Medicine, Director of Translational Research, and Associate Director for Clinical Science at Baylor College of Medicine She can be reached on Twitter at naborala Audio version of this episode: anchor.fm/chubbyemu/episodes/On-Breast-Malignancy-and-Military-Burn-Pit-Exp...
A Discussion On Over-The-Counter Cough Syrup Misuse
Переглядів 295 тис.2 роки тому
See @chubbyemu video ua-cam.com/video/WPxb2IG9MOk/v-deo.html Featuring: Dr Sonal Jagasia Patient GG depicted by @MerryRoseHowley Additional patient depictions by @JustinWhangYt Video with @JustinWhangYt : ua-cam.com/video/QKIobyk6Isc/v-deo.html Audio version of this podcast: anchor.fm/chubbyemu Tweet me: hemereview IG me: hemereview FB me: hemereview Dextr...
Hepatitis From Possibly Contaminated Alkaline Water
Переглядів 147 тис.3 роки тому
This video up to date as of April 11, 2021 Audio version: anchor.fm/chubbyemu/episodes/Hepatitis-From-Possibly-Contaminated-Alkaline-Water-euogm7 Statement from water company CEO: ua-cam.com/video/faCsru9Ctgk/v-deo.html @InsideEdition video about this case: ua-cam.com/video/lmEpmyc7g9Y/v-deo.html Local News talking about the water: ua-cam.com/video/oGQJcnlk5ag/v-deo.html On March 13, the FDA wa...
Why You Should Be Careful With Psyllium Husk Fiber Supplement
Переглядів 1,6 млн3 роки тому
​@chubbyemu video about Fiber Supplement: ua-cam.com/video/1MggKIfEld4/v-deo.html @HemeReview Audio-only episode A Grandma Collapsed From Abdominal Pain. This Is What Happened To Her Colon: anchor.fm/chubbyemu/episodes/A-Grandma-Collapsed-From-Abdominal-Pain This-Is-What-Happened-To-Her-Colon-eu9rol Psyllium husk fiber supplement can be part of a healthy diet, but it must be taken correctly. It...
Interview With A Stage 4 Lung Cancer Survivor (Jill Hamer-Wilson)
Переглядів 39 тис.3 роки тому
Audio-only Podcast version: anchor.fm/chubbyemu/episodes/Interview-With-A-Stage-4-Lung-Cancer-Survivor-Jill-Hamer-Wilson-etthjn Jill's Blog: throughthevalley.ca The White Ribbon Project: TheWRP4LC LUNGevity Foundation: lungevity.org GO2 Foundation: go2foundation.org Lung Cancer Canada: www.lungcancercanada.ca Lung Foundation Australia: lungfoundation.com.au Lung Cancer Europe (LUCe)...
A Discussion Of Dinitrophenol In Weight Loss
Переглядів 152 тис.3 роки тому
@East-Bound's personal recount of case: ua-cam.com/video/7BpymtR2vpA/v-deo.html @East-Bound Interview: ua-cam.com/video/o15HCjtSkug/v-deo.html @chubbyemu video on this case: ua-cam.com/video/ChPeG19qKUo/v-deo.html @HemeReview Podcast version: anchor.fm/chubbyemu 2,4-Dinitrophenol (DNP) is a chemical that is not approved for weight loss in the United States. It is a classic case of efficacy, but...
Conversation With A Rare Dinitrophenol Accident Survivor (DNP For Weight Loss)
Переглядів 409 тис.3 роки тому
Conversation With A Rare Dinitrophenol Accident Survivor (DNP For Weight Loss)
The Body After Eating Several Pounds Licorice Candy
Переглядів 288 тис.3 роки тому
The Body After Eating Several Pounds Licorice Candy
TikTokers Taking Too Much Benadryl
Переглядів 536 тис.3 роки тому
TikTokers Taking Too Much Benadryl
A Brief Discussion of Heatstroke
Переглядів 188 тис.3 роки тому
A Brief Discussion of Heatstroke
The Body After Drinking A Snowglobe
Переглядів 170 тис.3 роки тому
The Body After Drinking A Snowglobe
The Body After 2 Gallons Coffee In 3 Hours
Переглядів 286 тис.3 роки тому
The Body After 2 Gallons Coffee In 3 Hours
A Future Of Medicine
Переглядів 141 тис.4 роки тому
A Future Of Medicine
The Farmer Who Removed His Skin Cancer With A Pocket Knife
Переглядів 277 тис.4 роки тому
The Farmer Who Removed His Skin Cancer With A Pocket Knife
A Brief Discussion of Hydroxychloroquine In COVID-19 (March 2020)
Переглядів 101 тис.4 роки тому
A Brief Discussion of Hydroxychloroquine In COVID-19 (March 2020)
Understanding COVID-19 From Cases Described By Doctors In China
Переглядів 150 тис.4 роки тому
Understanding COVID-19 From Cases Described By Doctors In China

КОМЕНТАРІ

  • @Travelmoreoften
    @Travelmoreoften 5 годин тому

    I just want to know what exactly treatment helped her, anyone know?

  • @gc31
    @gc31 8 годин тому

    eMOO or eMU?

  • @Majorpain32677
    @Majorpain32677 22 години тому

    People have been taking Benadryl for slwep for decades this is about taking too much im a us coast guard veteran benadryl has great uses just dont take more than 1 or 2 , not freaking 12

  • @Majorpain32677
    @Majorpain32677 22 години тому

    We dont need to know how it works we need to teAch kids to not be stupid ive done my share im 47 years old kids always do stupid stuff problem is people not diagnosing why they want to do it as a Christian now i never have a desire its insane and shiws danger of social media and Kids that srent Christians

  • @NinjaBMXracing
    @NinjaBMXracing День тому

    😊

  • @zeev
    @zeev День тому

    probably your most important video you ever made. in it's practical effects. why? most people aren't eating rancid food, or exotic non-food items , or excess nitcotine or caffiene. many people do drink cofffee regularly.

  • @jessica_clark1725
    @jessica_clark1725 3 дні тому

    Vertigo anyone?

  • @AdamAdam-ut7dn
    @AdamAdam-ut7dn 4 дні тому

    I watched the full video but still don't know what's the right amount of water to mix with? Should I consume it when its still liquid or when its become jelly like.

  • @LegendFromWoW
    @LegendFromWoW 4 дні тому

    I’m taking medical courses right now for the first time in my life. This video makes things crystal clear to me and based off some inherited risks for heart attack I’ll probably no longer be intaking caffeine. I’ve also quit smoking so my lungs aren’t covered in tar and can function correctly.

  • @smithy1011
    @smithy1011 5 днів тому

    I’ve been drinking caffeine drinks and pre-workout for 17 years now, I usually aim for 200mg to max 400mg in any given day. I can go like 3 months before I get too run down and need at-least a 3 day break usually because I get sick because I’m so worn out at that stage. I can give it up straight away and I do get the withdrawal symptoms for first 3 days at least which for me is Tiredness (probably built up) speech is mumbo jumbo and I feel so mellow that a meteor could crash and I’d be like meh 🤷🏽‍♂️. I find caffeine makes life so fast paced and everyday I’m buzzing talking 200mph 😂……I know I probably wreck people’s heads but seeing your video and reading comments about clarity and peacefulness sounds interesting….im going to start today without caffeine 😅 maybe I might ascend with this abstinence 😂

  • @johnvonshepard9373
    @johnvonshepard9373 5 днів тому

    zzz

  • @andrewtennenbaum2263
    @andrewtennenbaum2263 5 днів тому

    Note to self: if I find a skin cancer leave it the fuck alone & let the doctors remove it

  • @MirkoSelf
    @MirkoSelf 5 днів тому

    In my opinion, coffee with ginger and also lemon brings another level into the body. Its very healthy in my experience. But great video, if too much everything becomes evil

  • @thanatosor
    @thanatosor 5 днів тому

    Don't let coffee ruin your life. Be brave to get rid of it. Scientists researched this deep enough to let big corps take use of this drug to make us addicted to it for years... draining health & money we spend on it.

  • @spectralcoffee5177
    @spectralcoffee5177 6 днів тому

    Bro you getting withdrawal must be some placebo, i have drunk coffe everyday since i was a kid, and i tried not drinking any coffee for a month, and there was not even a signle sign of headace. dramatic bro

  • @bperez8656
    @bperez8656 7 днів тому

    SOLUBLE FIBER (FRUITS) And MAGNESIUM CITRATE IS WHERE ITS AT TRUST ME PPL ❤❤❤❤

  • @lucaissewell
    @lucaissewell 7 днів тому

    You use the term pretext incorrectly

  • @HotRod12667
    @HotRod12667 10 днів тому

    Benadryl has no effect on me. I was taking a leukotriene receptor antagonist, known as montelukast, for asthma and allergies.

  • @HotRod12667
    @HotRod12667 10 днів тому

    I used to drink a lot of caffeinated beverages, including a pot of coffee a day. I would get headaches and crankiness as withdrawal. I then cut back to four cups of coffee a day but now down to two. If I miss a day I get a niggly headache but nothing that I can't deal with.

  • @longhealthyjoyfullife
    @longhealthyjoyfullife 10 днів тому

    Great video. Nice catch 😊

  • @donaldwood7449
    @donaldwood7449 10 днів тому

    If you ever need to poo, just eat McDonalds breakfast before an appointment of any kind. You will poo. Oh yes, you will poo.

  • @mrprongles9510
    @mrprongles9510 11 днів тому

    Yeeep exactly that took 1 and a half years of good sleep from me when I started eating vegetarian. In the beginning it wasn't as bad but after a few years I started sleeping worse and worse until I couldn't sleep almost every night. Recently I started eating meat again and low and behold I could sleep again. Now that I know what caused my insomnia I will probably supplement B12 and drop meat again.

  • @mohitpathak4225
    @mohitpathak4225 11 днів тому

    A cup of south indian filter coffee in the morning and my 40 min drive to work with radiohead on the music system. Pure bliss

  • @yadrak2354
    @yadrak2354 15 днів тому

    Dude, I just wanted to say how amazing you are. You start off from humble beginnings. Somehow educated yourself and became a toxicologist working in and ER. Produce some of the most entertaining and helpful content on youtube. I think you may have even helped me inadvertently with finding something to help me with my brachycardia. I took one dose of B1 last night around 10pm and so far as of 0600hrs haven't noticed any drops as lower as they were between 46-51 for my low. It's averaging in the 80's now. Still have a bit of an arythmia as noted by Paramedics when they came out to see me about 5 days ago when my blood sugars got dangerously low 54 on my meter 34 on theirs. I wanted to ask do you have any videos abotu diabetics and dangers of too high or too low blood sugar and what happens to people when their blood sugars are too high for too long or too low for too long and the damage this causes?

  • @user-zx8qq1so7j
    @user-zx8qq1so7j 16 днів тому

    First of all you are too young and are very lost about these things, cough syrup with Codiene was a very cheap buzz okay folks then did not have pockets full of credit and cash everywhere 2-3 guys could chip in and get high for 2 bucks this is why is very popular Benlyn was very popular way before Robotussin was ever born the other wasTussinex both with Codeine the second lots of it and not One Person OD'd and died or lost their minds like is common presently..

  • @robert_costello
    @robert_costello 16 днів тому

    It was, and still is, nothing more than the phucking flu

  • @Kevin-qj7fp
    @Kevin-qj7fp 17 днів тому

    i dont drink coffee but when i do it only takes a shot of coffee and a tiny sip in the morning to wake me up for the entire day well thats was the one time i realized how effective a tiny sip of coffee did to me as it woke me up

  • @mochigote
    @mochigote 17 днів тому

    Dr. Tannir is a hero man

  • @gmarefan
    @gmarefan 20 днів тому

    The tablets I take for mucus rarely has Dextromethorphan Hydrobromide 60mg extended release and the single dose is enough to make me feel euphoric. I don't take it to feel high but it is a side effect. I do also get tipsy very quickly on alcohol. I wonder if my sensitivities in general are very high.

  • @Slotty_Botfast
    @Slotty_Botfast 20 днів тому

    Psyllium husk makes me poop

  • @AlperenBozkurt-tx2bx
    @AlperenBozkurt-tx2bx 20 днів тому

    I want some dinitrophenol

  • @williamgee6654
    @williamgee6654 20 днів тому

    WHISKEY TRY IT

  • @jasonconstantine1811
    @jasonconstantine1811 21 день тому

    Who is taking a pound of psyllium husk?

  • @TenmasSchoolOfThought
    @TenmasSchoolOfThought 22 дні тому

    4:24 I studied this for my last hydrology course. The US federal mandatory only made sure the water cant kill you. 😂it only RECOMMENDS the municipalities to make it clean. So getting teeth discoloration wnd stuff is totally legal.

  • @TenmasSchoolOfThought
    @TenmasSchoolOfThought 22 дні тому

    2:31 sounds about right

  • @Amira22212
    @Amira22212 23 дні тому

    I just went through refeeding syndrome. I thought I was going to die. Thankfully my heart rhythm has gone back normal and my blood works is near normal. Have milk and yogurt at the beginning of the meal as it has phosphorus, small meals.

  • @matthewdanko4064
    @matthewdanko4064 24 дні тому

    I cut myself down to 2 cups a day at most! I haven't had to eat a Tums since that day

  • @elmate666666
    @elmate666666 24 дні тому

    Anyone knows if taken with food it alters food absorption? Or just sups?

  • @jameswierdchannel744
    @jameswierdchannel744 24 дні тому

    I use a single teaspon to a Big glad 400-500 mil

  • @jameswierdchannel744
    @jameswierdchannel744 24 дні тому

    Only use tea spoon to 400mil

  • @aldovalerio1067
    @aldovalerio1067 26 днів тому

    I am very susceptible to caffeine and I love coffee, drinking it in the morning is a ritual for me. What I have done is that I put half a half of normal coffee with half of decaffeinated and it has worked very well for me. I love it.

  • @RipCityStreetfighter503
    @RipCityStreetfighter503 26 днів тому

    That’s why it’s only 2 tablespoons spoons, who is dumping half the container in a cup of water lol

  • @allenabrams-dw4hy
    @allenabrams-dw4hy 26 днів тому

    When I was young, I put Bengay on my calf muscles and proceeded to take a shower. I rubbed it everywhere, by accident. Screw the medical jargon, this was terrible enough. Make sure your affected area is dry before showering.

  • @marviemendoza6157
    @marviemendoza6157 27 днів тому

    Can I eati vegeratablr and fruits even I take Cilliim fiber

  • @jupiter452
    @jupiter452 27 днів тому

    2 days of coffee and you throwing up? Can't relate...

  • @baronunderbeit7723
    @baronunderbeit7723 28 днів тому

    lol. note to self. don't eat 2 POUNDS of fibre supplement. Honestly this is like a Darwin award if you do what this guy is saying as the worst case.

  • @eloisesummerfield7763
    @eloisesummerfield7763 28 днів тому

    I keep trying to get this message across. There is a real risk when taking opioids - need a stimulant and plenty of fluid.

  • @bencheevers6693
    @bencheevers6693 29 днів тому

    There was a drunk in the Early US that hung around a shady bar and they took out a life insurance policy on him because they thought he'd drink himself to death but when he was still around they thought they'd hurry up the process so they would get him hammered and then switch the booze to wood or rubbing alcohol, it was something like that. He survived an extreme amount of toxic alcohol for a little while at least, like enough to kill a lot of people very quickly because he was so drunk all the time, Dankula has a madlad video on him but I forget the name

  • @isabellemyzer1807
    @isabellemyzer1807 Місяць тому

    Lol

  • @Glitterdagger
    @Glitterdagger Місяць тому

    “Before arriving to DC Camera- full circle- I had to stop at a Target” cleverrrrrr